gpDB: a database of GPCRs, G-proteins, Effectors and their interactions
Introduction Navigation Text Search Blast Search Pattern Search User Manual

gpDB::Effector View
Entry 1 of 1 :: EFF0861 ::
FAMILY Tyr protein kinases
SUBFAMILY Tyr protein kinases
TYPE Src tyrosine kinase

Cross References:
UniProt P41241 | Q03143 EMBL U05247 | X57242
InterPro IPR015778 | IPR000719 | IPR000980 | IPR001452 | IPR001245 | IPR008266 PDB 1JEG
PRODOM PD000001 | PD000093 | PD000066
PRINTS PR00401 | PR00452 | PR00109 PFAM PF07714 | PF00017 | PF00018

Details:
NAME Src tyrosine kinase-Mus musculus-3
DESCRIPTION Tyrosine-protein kinase CSK (EC 2.7.10.2) (C-SRC kinase) (Protein-tyrosine kinase MPK-2) (p50CSK).
SPECIES Mus musculus COMMON NAME Mouse NCBI Taxonomy 10090
GENE Csk
SEQUENCE 
MSAIQAAWPSGTECIAKYNFHGTAEQDLPFCKGDVLTIVAVTKDPNWYKAKNKVGREGII
PANYVQKREGVKAGTKLSLMPWFHGKITREQAERLLYPPETGLFLVRESTNYPGDYTLCV
SCEGKVEHYRIMYHASKLSIDEEVYFENLMQLVEHYTTDADGLCTRLIKPKVMEGTVAAQ
DEFYRSGWALNMKELKLLQTIGKGEFGDVMLGDYRGNKVAVKCIKNDATAQAFLAEASVM
TQLRHSNLVQLLGVI
 FRAGMENT NO
FUNCTION Specifically phosphorylates 'Tyr-504' on LCK, which actss as a negative regulatory site
Interacting with G-proteins:
Family:Gi/o REFERENCES:11007482 | 15251227 | 12209124
1GPR0227Galpha-i2-Mus musculus-2
2GPR0289Galpha-i1-Mus musculus
3GPR0331Galpha-i2-Mus musculus-1
4GPR0385Galpha-i3-Mus musculus
5GPR0021Galpha-o1-Mus musculus
Family:Gs REFERENCES:11007482 | 15251227 | 12209124
6GPR0123Galpha-s-Mus musculus-2
7GPR0391Galpha-s-Mus musculus

Designed for viewing with Internet Explorer 4 or above, Netscape 6 or above.
contact biodbbiol.uoa.gr
for comments, corrections and
data (sequence) submission.
athina University of Athens
 Faculty of Biology
 Dept. of Cell Biology and Biophysics
Biophysics
& Bioinformatics
Laboratory