gpDB: a database of GPCRs, G-proteins, Effectors and their interactions
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gpDB::GPCR View
Entry 1 of 1 :: GPCR1223 ::
CLASS CLASS A (RHODOPSIN LIKE)
FAMILY MELATONIN RECEPTOR
SUBFAMILY MT1

Cross References:
UniProt P49219 EMBL U09561
InterPro IPR000276 | IPR002279 | IPR000025 GPCRDB MTR1C_XENLA
GENEID 397808
PRINTS PR00237 | PR01150 | PR00857 PFAM PF00001

Details:
NAME MELATONIN RECEPTOR_MT1_Xenopus laevis-1
DESCRIPTION Melatonin receptor type 1C (MEL-1C-R).
SPECIES Xenopus laevis COMMON NAME African clawed frog NCBI Taxonomy 8355
GENE -
SEQUENCE
MMEVNSTCLDCRTPGTIRTEQDAQDSASQGLTSALAVVLIFTIVVDVLGNILVILSVLRN
KKLQNAGNLFVVSLSIADLVVAVYPYPVILIAIFQNGWTLGNIHCQISGFLMGLSVIGSV
FNITAIAINRYCYICHSLRYDKLYNQRSTWCYLGLTWILTIIAIVPNFFVGSLQYDPRIF
SCTFAQTVSSSYTITVVVVHFIVPLSVVTFCYLRIWVLVIQVKHRVRQDFKQKLTQTDLR
NFLTMFVVFVLFAVCWAPLNFIGLAVAINPFHVAPKIPEWLFVLSYFMAYFNSCLNAVIY
GVLNQNFRKEYKRILMSLLTPRLLFLDTSRGGTEGLKSKPSPAVTNNNQADMLGEARSLW
LSRRNGAKMVIIIRPRKAQIAIIHQIFWPQSSWATCRQDTKITGEEDGCRELCKDGISQR
FRAGMENT NO

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Dimerization:
HOMODIMER INFORMATION There is experimental evidence for homo-dimerization METHOD Immunoprecipitation, Bioluminescence Resonance Energy Transfer (BRET) REFERENCES 11940583
HETERODIMER INFORMATION Forms heterodimers with Melatonin MT2 Receptors. METHOD Immunoprecipitation, Bioluminescence Resonance Energy Transfer (BRET) REFERENCES 11940583

Coupling with G-proteins:
Family:Gi/o REFERENCES:7946354
1GPR0016Galpha-o-Xenopus laevis
2GPR0112Galpha-i3-Xenopus laevis
3GPR0222Galpha-i1-Xenopus laevis
4GPR0271Galpha-o1-Xenopus laevis
5GPR0272Galpha-i-Xenopus laevis


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athina University of Athens
Faculty of Biology
Dept. of Cell Biology and Biophysics
Biophysics
& Bioinformatics
Laboratory