gpDB: a database of GPCRs, G-proteins, Effectors and their interactions
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gpDB::GPCR View
Entry 1 of 1 :: GPCR1254 ::
CLASS CLASS A (RHODOPSIN LIKE)
FAMILY NEUROPEPTIDE Y RECEPTOR
SUBFAMILY Y2

Cross References:
UniProt P49146 | Q13281 | Q13457 | Q6AZZ6 | Q9UE67 EMBL U36269 | U42766 | U32500 | U42389 | U50146 | U76254 | AY236540 | BC075053 | BC075052
InterPro IPR000276 | IPR001358 | IPR000611 PDB 2IK3 GPCRDB NPY2R_HUMAN
GENEID 4887 MIM 162642
PRINTS PR00237 | PR01014 | PR01012 PFAM PF00001

Details:
NAME NEUROPEPTIDE Y RECEPTOR_Y2_Homo sapiens
DESCRIPTION Neuropeptide Y receptor type 2 (NPY2-R) (NPY-Y2 receptor).
SPECIES Homo sapiens COMMON NAME Human NCBI Taxonomy 9606
GENE NPY2R
SEQUENCE 
MGPIGAEADENQTVEEMKVEQYGPQTTPRGELVPDPEPELIDSTKLIEVQVVLILAYCSI
ILLGVIGNSLVIHVVIKFKSMRTVTNFFIANLAVADLLVNTLCLPFTLTYTLMGEWKMGP
VLCHLVPYAQGLAVQVSTITLTVIALDRHRCIVYHLESKISKRISFLIIGLAWGISALLA
SPLAIFREYSLIEIIPDFEIVACTEKWPGEEKSIYGTVYSLSSLLILYVLPLGIISFSYT
RIWSKLKNHVSPGAANDHYHQRRQKTTKMLVCVVVVFAVSWLPLHAFQLAVDIDSQVLDL
KEYKLIFTVFHIIAMCSTFANPLLYGWMNSNYRKAFLSAFRCEQRLDAIHSEVSVTFKAK
KNLEVRKNSGPNDSFTEATNV
 FRAGMENT NO

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Dimerization:
HOMODIMER INFORMATION There is experimental evidence for homo-dimerization METHOD Fluorescence Resonance Energy Transfer (FRET) REFERENCES 12524448

Coupling with G-proteins:
Family:Gi/o REFERENCES:7559383
1GPR0020Galpha-o1-Homo sapiens
2GPR0109Galpha-i3-Homo sapiens
3GPR0218Galpha-i1-Homo sapiens-1
4GPR0226Galpha-i2-Homo sapiens-2
5GPR0261Galpha-i1-Homo sapiens-2
6GPR0334Galpha-o-Homo sapiens
7GPR0365Galpha-i2-Homo sapiens-1

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athina University of Athens
 Faculty of Biology
 Dept. of Cell Biology and Biophysics
Biophysics
& Bioinformatics
Laboratory