gpDB: a database of GPCRs, G-proteins, Effectors and their interactions
Introduction Navigation Text Search Blast Search Pattern Search User Manual

gpDB::GPCR View
Entry 1 of 1 :: GPCR0168 ::
CLASS CLASS A (RHODOPSIN LIKE)
FAMILY ADENOSINE RECEPTOR
SUBFAMILY A1

Cross References:
UniProt P30542 | Q8TAM8 EMBL S45235 | S56143 | L22214 | X68485 | AB004662 | AY136746 | BT019854 | BC026340
InterPro IPR001068 | IPR001634 | IPR000276 GPCRDB AA1R_HUMAN
GENEID 134 MIM 102775
PRINTS PR00552 | PR00424 | PR00237 PFAM PF00001

Details:
NAME ADENOSINE RECEPTOR_A1_Homo sapiens
DESCRIPTION Adenosine receptor A1.
SPECIES Homo sapiens COMMON NAME Human NCBI Taxonomy 9606
GENE ADORA1
SEQUENCE
MPPSISAFQAAYIGIEVLIALVSVPGNVLVIWAVKVNQALRDATFCFIVSLAVADVAVGA
LVIPLAILINIGPQTYFHTCLMVACPVLILTQSSILALLAIAVDRYLRVKIPLRYKMVVT
PRRAAVAIAGCWILSFVVGLTPMFGWNNLSAVERAWAANGSMGEPVIKCEFEKVISMEYM
VYFNFFVWVLPPLLLMVLIYLEVFYLIRKQLNKKVSASSGDPQKYYGKELKIAKSLALIL
FLFALSWLPLHILNCITLFCPSCHKPSILTYIAIFLTHGNSAMNPIVYAFRIQKFRVTFL
KIWNDHFRCQPAPPIDEDLPEERPDD
FRAGMENT NO

Homepage

Dimerization:
HOMODIMER INFORMATION There is experimental evidence for homo-dimerization METHOD Bioluminescence Resonance Energy Transfer (BRET) REFERENCES 12123822
HETERODIMER INFORMATION Forms heterodimers with Dopamine D1 Receptor. Heterodimerization results in altered D1 receptor signalling METHOD Immunoprecipitation REFERENCES 10890919
HETERODIMER INFORMATION Forms heterodimers with Metabotropic Glutamate Receptor 1. Dimerization results in alteration of signalling METHOD Immunoprecipitation REFERENCES 11278325
HETERODIMER INFORMATION Forms heterodimers with P2Y1 Receptors. Heterodimerization results in altered ligand binding METHOD Immunoprecipitation, Bioluminescence Resonance Energy Transfer (BRET) REFERENCES 11390975 | 12417330 | 12123822

Coupling with G-proteins:
Family:Gi/o REFERENCES:1662665
1GPR0020Galpha-o1-Homo sapiens
2GPR0109Galpha-i3-Homo sapiens
3GPR0218Galpha-i1-Homo sapiens-1
4GPR0226Galpha-i2-Homo sapiens-2
5GPR0261Galpha-i1-Homo sapiens-2
6GPR0334Galpha-o-Homo sapiens
7GPR0365Galpha-i2-Homo sapiens-1


Designed for viewing with Internet Explorer 4 or above, Netscape 6 or above.
contact biodbbiol.uoa.gr
for comments, corrections and
data (sequence) submission.
athina University of Athens
Faculty of Biology
Dept. of Cell Biology and Biophysics
Biophysics
& Bioinformatics
Laboratory