gpDB: a database of GPCRs, G-proteins, Effectors and their interactions
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gpDB::GPCR View
Entry 1 of 1 :: GPCR1891 ::
CLASS CLASS A (RHODOPSIN LIKE)
FAMILY OPIOID AND OPIOID-LIKE RECEPTOR
SUBFAMILY KAPPA OPIOID PEPTIDE (KOR)

Cross References:
UniProt Q8WNX7 EMBL L49437
InterPro IPR000276 | IPR000452 | IPR001418 GPCRDB Q8WNX7_PIG
PRINTS PR00237 | PR00532 | PR00384 PFAM PF00001

Details:
NAME OPIOID AND OPIOID-LIKE RECEPTOR_KAPPA OPIOID PEPTIDE (KOR)_Sus scrofa-1
DESCRIPTION Kappa opioid receptor .
SPECIES Sus scrofa COMMON NAME Pig NCBI Taxonomy 9823
GENE -
SEQUENCE
VYLMNSWPFGDVLCKIVISIDYYNMFTSIFTLTMMSVDRYIAVCHPVKALDFRTPLKAKI
INICIWILSSSVGISAIVLGGTKVREDVDVIECSLQFPDDDYSWWDLFVKLCVFVFAFVI
PVLIIIVCYTLMILRLKSVRLLSGSREKDRNLRRITRLVLKVVAVFVVCWTPIHIFILVE
ALGSTSHSTAALSSYYFCIALGYTNSSLNPILYAFLDENFKRCFRDFCFPVKVRMERQST
SRIKNTVQDPAY
FRAGMENT YES

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Dimerization:
HOMODIMER INFORMATION There is experimental evidence for homo-dimerization METHOD Immunoprecipitation REFERENCES 10385123
HETERODIMER INFORMATION Forms heterodimers with delta Opioid Peptide Receptor. Dimerization results in altered ligand binding, potentiated signalling and altered internalization METHOD Immunoprecipitation REFERENCES 10385123
HETERODIMER INFORMATION Forms heterodimers with B2 Adrenoceptors. Heterodimerization results in altered internalization and MAPK signalling METHOD Immunoprecipitation REFERENCES 11134510

Scaffold:
TYPE NHERF1( Na+/H+ exchange regulatory factor) /EBP50( ezrin-radixin-moesin binding phosphoprotein 50-kD protein) REFERENCES 12004055

Coupling with G-proteins:
No information


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