gpDB: a database of GPCRs, G-proteins, Effectors and their interactions
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gpDB::GPCR View
Entry 1 of 1 :: GPCR0219 ::
CLASS CLASS A (RHODOPSIN LIKE)
FAMILY ADRENOCEPTOR (A1-ADRENOCEPTOR)
SUBFAMILY A1B(Adrenoceptor)

Cross References:
UniProt Q9WU27 EMBL AF108018
InterPro IPR002233 | IPR000276 GPCRDB Q9WU27_CAVPO
PRINTS PR01103 | PR00237 PFAM PF00001

Details:
NAME ADRENOCEPTOR (A1-ADRENOCEPTOR)_A1B(Adrenoceptor)_Cavia porcellus
DESCRIPTION Alpha-1B adrenergic receptor .
SPECIES Cavia porcellus COMMON NAME Guinea pig NCBI Taxonomy 10141
GENE ADRA1B
SEQUENCE 
FIVNLASADLLLSFTVLPFSATLEVLGYWVLGRIFCDIWAAVDVLCCTASILSLCAISID
RYIGVRYSLRYPTLVTRRKAILALLSVWVLSTVIPIGPLLGWKEPAPNDDKECGVTEEPF
YALFSSLGSFYIPLAVILVM
 FRAGMENT YES

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Dimerization:
HOMODIMER INFORMATION There is experimental evidence for homo-dimerization METHOD Immunoprecipitation, Fluorescence Resonance Energy Transfer (FRET) REFERENCES 12888550
HETERODIMER INFORMATION Forms heterodimers with A1A Adrenoceptors. Heterodimerization results in altered internalization of the receptor METHOD Fluorescence Resonance Energy Transfer (FRET) REFERENCES 12888550

Scaffold:
TYPE nNOS( neuronal nitric oxide synthase) NOS1 REFERENCES 12184796

Coupling with G-proteins:
No information

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