gpDB: a database of GPCRs, G-proteins, Effectors and their interactions
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gpDB::GPCR View
Entry 1 of 1 :: GPCR0237 ::
CLASS CLASS A (RHODOPSIN LIKE)
FAMILY ADRENOCEPTOR (A2-ADRENOCEPTOR)
SUBFAMILY A2A(Adrenoceptor)

Cross References:
UniProt P18871 EMBL J05652
InterPro IPR001946 | IPR015695 | IPR002233 | IPR000276 GPCRDB ADA2A_PIG
GENEID 399501
PRINTS PR01103 | PR00558 | PR00237 PFAM PF00001

Details:
NAME ADRENOCEPTOR (A2-ADRENOCEPTOR)_A2A(Adrenoceptor)_Sus scrofa
DESCRIPTION Alpha-2A adrenergic receptor (Alpha-2A adrenoceptor) (Alpha-2Aadrenoreceptor) (Alpha-2AAR).
SPECIES Sus scrofa COMMON NAME Pig NCBI Taxonomy 9823
GENE ADRA2A | A2AR
SEQUENCE
MGSLQPEAGNASWNGTEAPGGGARATPYSLQVTLTLVCLAGLLMLFTVFGNVLVIIAVFT
SRALKAPQNLFLVSLASADILVATLVIPFSLANEVMGYWYFGKAWCEIYLALDVLFCTSS
IVHLCAISLDRYWSITQAIEYNLKRTPRRIKAIIVTVWVISAVISFPPLISIEKKAGGGG
QQPAEPRCEINDQKWYVISSCIGSFFAPCLIMILVYVRIYQIAKRRTRVPPSRRGPDAAA
ALPGGAERRPNGLGPERGVGRVGAEAEPLPVQLNGAPGEPAPAGPRDADGLDLEESSSSE
HAERPPGPRRSERGPRAKSKARASQVKPGDSLPRRGPGAPGPGAPATGAGEERGGVAKAS
RWRGRQNREKRFTFVLAVVIGVFVVCWFPFFFTYTLTAVGCSVPPTLFKFFFWFGYCNSS
LNPVIYTIFNHDFRRAFKKILCRGDRKRIV
FRAGMENT NO

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Dimerization:
HETERODIMER INFORMATION Forms heterodimers with B1 Adrenoceptors. Heterodimerization results in altered ligand binding and internalization of the receptor METHOD Immunoprecipitation REFERENCES 12529373

Scaffold:
TYPE 14-3-3 ksi REFERENCES 10224112
TYPE Spinophilin/neurabin II REFERENCES 11154706

Coupling with G-proteins:
Family:Gs REFERENCES:8662784
1GPR0125Galpha-s-Sus scrofa


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athina University of Athens
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Dept. of Cell Biology and Biophysics
Biophysics
& Bioinformatics
Laboratory