gpDB: a database of GPCRs, G-proteins, Effectors and their interactions
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gpDB::GPCR View
Entry 1 of 1 :: GPCR2475 ::
CLASS CLASS A (RHODOPSIN LIKE)
FAMILY SOMATOSTATIN RECEPTOR
SUBFAMILY SST1

Cross References:
UniProt P30873 EMBL M81831
InterPro IPR000276 | IPR000586 | IPR001116 GPCRDB SSR1_MOUSE
GENEID 20605
PRINTS PR00237 | PR00246 | PR00587 PFAM PF00001

Details:
NAME SOMATOSTATIN RECEPTOR_SST1_Mus musculus
DESCRIPTION Somatostatin receptor type 1 (SS1R) (SRIF-2).
SPECIES Mus musculus COMMON NAME Mouse NCBI Taxonomy 10090
GENE Sstr1 | Smstr1
SEQUENCE
MFPNGTASSPSSSPSPSPGSCGEGACSRGPGSGAADGMEEPGRNASQNGTLSEGQGSAIL
ISFIYSVVCLVGLCGNSMVIYVILRYAKMKTATNIYILNLAIADELLMLSVPFLVTSTLL
RHWPFGALLCRLVLSVDAVNMFTSIYCLTVLSVDRYVAVVHPIKAARYRRPTVAKVVNLG
VWVLSLLVILPIVVFSRTAANSDGTVACNMLMPEPAQRWLVGFVLYTFLMGFLLPVGAIC
LCYVLIIAKMRMVALKAGWQQRKRSERKITLMVMMVVMVFVICWMPFYVVQLVNVFAEQD
DATVSQLSVILGYANSCANPILYGFLSDNFKRSFQRILCLSWMDNAAEEPVDYYATALKS
RAYSVEDFQPENLESGGVFRNGTCASRISTL
FRAGMENT NO

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Dimerization:
HOMODIMER INFORMATION There is experimental evidence for homo-dimerization METHOD Immunoprecipitation, Fluorescence Resonance Energy Transfer (FRET) REFERENCES 10713101
HETERODIMER INFORMATION Forms heterodimer with SST5 Receptor. Dimerization allows internalization of SST1 Receptor METHOD Photobleaching Fluorescence Resonance Energy Transfer (FRET) REFERENCES 10713101

Coupling with G-proteins:
Family:Gi/o REFERENCES:1346068
1GPR0021Galpha-o1-Mus musculus
2GPR0227Galpha-i2-Mus musculus-2
3GPR0289Galpha-i1-Mus musculus
4GPR0331Galpha-i2-Mus musculus-1
5GPR0385Galpha-i3-Mus musculus


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athina University of Athens
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Biophysics
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Laboratory