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gpDB::GPCR View
Entry 1 of 1 :: GPCR0326 ::
CLASS CLASS A (RHODOPSIN LIKE)
FAMILY ADRENOCEPTOR (B-ADRENOCEPTOR)
SUBFAMILY B2(Adrenoceptor)

Cross References:
UniProt Q8UUY8 EMBL AY044093
InterPro IPR000332 | IPR002233 | IPR000276 GPCRDB ADRB2_ONCMY
PRINTS PR01103 | PR00237 PFAM PF00001

Details:
NAME ADRENOCEPTOR (B-ADRENOCEPTOR)_B2(Adrenoceptor)_Oncorhynchus mykiss
DESCRIPTION Beta-2 adrenergic receptor (Beta-2 adrenoceptor) (Beta-2adrenoreceptor).
SPECIES Oncorhynchus mykiss COMMON NAME Rainbow trout NCBI Taxonomy 8022
GENE adrb2
SEQUENCE
MENVSTPAVFNLSDLSVEMNSSSRQWSYSEYSEAVAVLLGILMALLVMCIVFGNVLVITA
IVRFQRLQTVTNMFITSLACADLVMGLLVVPFGACYILLNTWHFGSFLCEFWTAADVLCV
TASIETLCVIALDRYLAITSPLRYPSLLTKRKACVVVVTVWGVAALISFLPIHMKWWVSD
EPEALSCLEDAHCCDFNTNAAYAVASSVVSFYIPLAVMAFVYGRVFQEARKQLEKIRGSE
GRFHAQMIDNNQGQDGGDGSGGGGGNGKRPKFCLKEHKALKTLGIIMGTFTLCWLPFFVL
NVVVTIWKVDNIKMPFRILNWIGYANSAFNPLIYCRSPEFRYAFQEILCLRGAAFPTNGY
IYRGHSLRLSPKDKPGSLSNNVGTVELGSLSSVTNINGYCNNPPLASIV
FRAGMENT NO

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Dimerization:
HOMODIMER INFORMATION There is experimental evidence for homo-dimerization METHOD Bioluminescence Resonance Energy Transfer (BRET) REFERENCES 10725388 | 12140284
HOMODIMER INFORMATION There is experimental evidence for homo-dimerization METHOD Immunoprecipitation REFERENCES 10725388 | 8663163
HETERODIMER INFORMATION Forms heterodimers with delta Opioid Receptors. Heterodimerization results in altered internalization and MAPK signalling METHOD Immunoprecipitation, Bioluminescence Resonance Energy Transfer (BRET), Time-Resolved Fluorescence Resonance Energy Transfer (TR-FRET) REFERENCES 11134510 | 11278447
HETERODIMER INFORMATION Forms heterodimers with kappa Opioid Receptors. Heterodimerization results in altered internalization and MAPK signalling METHOD Immunoprecipitation REFERENCES 11134510
HETERODIMER INFORMATION Forms heterodimers with B1 Adrenoceptors. Dimerization results in inhibiting internalization and ERK activation by B2 Adrenoceptor METHOD Bioluminescence Resonance Energy Transfer (BRET) REFERENCES 12244098
HETERODIMER INFORMATION Forms heterodimers with B1 Adrenoceptors. Dimerization results in inhibiting internalization and ERK activation by B2 Adrenoceptor METHOD Immunoprecipitation REFERENCES 12140284

Scaffold:
TYPE AKAP250( A-kinase anchoring protein 250) /gravin REFERENCES 11309381
TYPE AKAP79( A-kinase anchoring protein 79) REFERENCES 10753752 | 1127846
TYPE GASP( GPCR associated sorting protein) REFERENCES 12142540
TYPE NHERF1( Na+/H+ exchange regulatory factor) /EBP50( ezrin-radixin-moesin binding phosphoprotein 50-kD protein) REFERENCES 10499588 | 9671706 | 9560162
TYPE NHERF2/E3 KARP REFERENCES 9560162
TYPE NSF( N-ethylmaleimide-sensitive factor) REFERENCES 11278469

Coupling with G-proteins:
No information


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athina University of Athens
Faculty of Biology
Dept. of Cell Biology and Biophysics
Biophysics
& Bioinformatics
Laboratory