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gpDB::GPCR View
Entry 1 of 1 :: GPCR0380 ::
CLASS CLASS A (RHODOPSIN LIKE)
FAMILY ADRENOCEPTOR (B-ADRENOCEPTOR)
SUBFAMILY B2(Adrenoceptor)

Cross References:
UniProt Q9BFW3 EMBL AY011309
InterPro IPR000332 | IPR002233 | IPR000276 GPCRDB Q9BFW3_CANFA
PRINTS PR01103 | PR00562 | PR00237 PFAM PF00001

Details:
NAME ADRENOCEPTOR (B-ADRENOCEPTOR)_B2(Adrenoceptor)_Canis familiaris-2
DESCRIPTION Beta-2 adrenergic receptor .
SPECIES Canis familiaris COMMON NAME Dog NCBI Taxonomy 9615
GENE ADRB2
SEQUENCE
VLVITAIARFERLQTVTNYFITSLACADLVMGLAVVPFGASHILMKMWTFGNFWCEFWTS
IDVLCVTASIETLCVIAVDRYFAITSPFKYQSLLTKNKARVVILMVWIVSGLTSFLPIQM
HWYRATHQEAINCYAKETCCDFFTNQAYAIASSIVSFYLPLVVMVFVYSRVFQVAQRQLQ
KIDRSEGRFHAQNLSQVEQDGRSGHGHRRSSKFCLKEHKALKTLGIIMGTFTLCWLPFFI
VNIVHVIQDNLIPKEVYILLNWVGYVNSAFNPLIY
FRAGMENT YES

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Dimerization:
HOMODIMER INFORMATION There is experimental evidence for homo-dimerization METHOD Bioluminescence Resonance Energy Transfer (BRET) REFERENCES 10725388 | 12140284
HOMODIMER INFORMATION There is experimental evidence for homo-dimerization METHOD Immunoprecipitation REFERENCES 10725388 | 8663163
HETERODIMER INFORMATION Forms heterodimers with delta Opioid Receptors. Heterodimerization results in altered internalization and MAPK signalling METHOD Immunoprecipitation, Bioluminescence Resonance Energy Transfer (BRET), Time-Resolved Fluorescence Resonance Energy Transfer (TR-FRET) REFERENCES 11134510 | 11278447
HETERODIMER INFORMATION Forms heterodimers with kappa Opioid Receptors. Heterodimerization results in altered internalization and MAPK signalling METHOD Immunoprecipitation REFERENCES 11134510
HETERODIMER INFORMATION Forms heterodimers with B1 Adrenoceptors. Dimerization results in inhibiting internalization and ERK activation by B2 Adrenoceptor METHOD Bioluminescence Resonance Energy Transfer (BRET) REFERENCES 12244098
HETERODIMER INFORMATION Forms heterodimers with B1 Adrenoceptors. Dimerization results in inhibiting internalization and ERK activation by B2 Adrenoceptor METHOD Immunoprecipitation REFERENCES 12140284

Scaffold:
TYPE AKAP250( A-kinase anchoring protein 250) /gravin REFERENCES 11309381
TYPE AKAP79( A-kinase anchoring protein 79) REFERENCES 10753752 | 1127846
TYPE GASP( GPCR associated sorting protein) REFERENCES 12142540
TYPE NHERF1( Na+/H+ exchange regulatory factor) /EBP50( ezrin-radixin-moesin binding phosphoprotein 50-kD protein) REFERENCES 10499588 | 9671706 | 9560162
TYPE NHERF2/E3 KARP REFERENCES 9560162
TYPE NSF( N-ethylmaleimide-sensitive factor) REFERENCES 11278469

Coupling with G-proteins:
Family:Gs REFERENCES:3041227
1GPR0120Galpha-s-Canis familiaris


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athina University of Athens
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Dept. of Cell Biology and Biophysics
Biophysics
& Bioinformatics
Laboratory