gpDB: a database of GPCRs, G-proteins, Effectors and their interactions
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gpDB::GPCR View
Entry 1 of 1 :: GPCR0412 ::
CLASS CLASS A (RHODOPSIN LIKE)
FAMILY ANGIOTENSIN RECEPTOR
SUBFAMILY AT1

Cross References:
UniProt Q9WV26 EMBL AF165888
InterPro IPR000190 | IPR000248 | IPR001186 | IPR000276 GPCRDB AGTR1_CAVPO
PRINTS PR00241 | PR00635 | PR00993 | PR00237 PFAM PF00001

Details:
NAME ANGIOTENSIN RECEPTOR_AT1_Cavia porcellus-1
DESCRIPTION Type-1 angiotensin II receptor (AT1).
SPECIES Cavia porcellus COMMON NAME Guinea pig NCBI Taxonomy 10141
GENE AGTR1
SEQUENCE
MILNSSTEDGIKRIQDDCPKAGRHSYIFVMIPTLYSIIFVVGIFGNSLVVIVIYFYMKLK
TVASVFLLNLALADICFLLTLPLWAVYTAMEYRWPFGNYLCKIASASVSFNLYASVFLLT
CLSIDRYLAIVHPMKSRLRRTMLVAKVTCVIIWLMAGLASLPAVIHRNVFFIENTNITVC
AFHYESQNSTLPIGLGLTKNILGFMFPFLIILTSYTLIWKALKKAYEIQKNKPRNDDIFK
IIMAIVLFFFFSWVPHQIFTFLDVLIQLGIIHDCKISDIVDTAMPITICIAYFNNCLNPL
FYGFLGKKFKKYFLQLLKYIPPKAKSHSTLSTKMSTLSYRPSDNVSSSAKKPVQCFEVE
FRAGMENT NO

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Dimerization:
HOMODIMER INFORMATION There is experimental evidence for homo-dimerization METHOD functional complementation REFERENCES 8576145
HETERODIMER INFORMATION Forms heterodimer with AT2 Receptor. After the dimerization the AT2 receptor antagonizes function of the AT1 receptor METHOD Immunoprecipitation REFERENCES 11507095
HETERODIMER INFORMATION Forms heterodimer with Bradykinin B2 Receptor. Dimerization results in increased signalling activity METHOD Immunoprecipitation REFERENCES 10993080

Scaffold:
TYPE eNOS( endothelial nitric oxide synthase) /cNOS/NOS3 REFERENCES 12842859
TYPE JAK2( Janus kinase) REFERENCES 9287353

Coupling with G-proteins:
Family:Gi/o REFERENCES:1310139
1GPR0107Galpha-i3-Cavia porcellus
2GPR0216Galpha-i1-Cavia porcellus
3GPR0224Galpha-i2-Cavia porcellus


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athina University of Athens
Faculty of Biology
Dept. of Cell Biology and Biophysics
Biophysics
& Bioinformatics
Laboratory