gpDB: a database of GPCRs, G-proteins, Effectors and their interactions
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gpDB::GPCR View
Entry 1 of 1 :: GPCR0422 ::
CLASS CLASS A (RHODOPSIN LIKE)
FAMILY ANGIOTENSIN RECEPTOR
SUBFAMILY AT1

Cross References:
UniProt P33396 | Q92158 EMBL L23203 | S58041
InterPro IPR000190 | IPR000248 | IPR001186 | IPR000276 GPCRDB AGTR1_MELGA
PRINTS PR00241 | PR00635 | PR00993 | PR00237 PFAM PF00001

Details:
NAME ANGIOTENSIN RECEPTOR_AT1_Meleagris gallopavo
DESCRIPTION Type-1 angiotensin II receptor (AT1).
SPECIES Meleagris gallopavo COMMON NAME Common turkey NCBI Taxonomy 9103
GENE AGTR1
SEQUENCE
MVPNYSTEETVKRIHVDCPVSGRHSYIYIMVPTVYSIIFIIGIFGNSLVVIVIYCYMKLK
TVASIFLLNLALADLCFLITLPLWAAYTAMEYQWPFGNCLCKLASAGISFNLYASVFLLT
CLSIDRYLAIVHPVKSRIRRTMFVARVTCIVIWLLAGVASLPVIIHRNIFFAENLNMTVC
GFRYDNNNTTLRVGLGLSKNLLGFLIPFLIILTSYTLIWKTLKKAYQIQRNKTRNDDIFK
MIVAIVFFFFFSWIPHQVFTFLDVLIQLHVITDCKITDIVDTAMPFTICIAYFNNCLNPF
FYVFFGKNFKKYFLQLIKYIPPNVSTHPSLTTKMSSLSYRPPENIRLPTKKTAGSFDTE
FRAGMENT NO

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Dimerization:
HOMODIMER INFORMATION There is experimental evidence for homo-dimerization METHOD functional complementation REFERENCES 8576145
HETERODIMER INFORMATION Forms heterodimer with AT2 Receptor. After the dimerization the AT2 receptor antagonizes function of the AT1 receptor METHOD Immunoprecipitation REFERENCES 11507095
HETERODIMER INFORMATION Forms heterodimer with Bradykinin B2 Receptor. Dimerization results in increased signalling activity METHOD Immunoprecipitation REFERENCES 10993080

Scaffold:
TYPE eNOS( endothelial nitric oxide synthase) /cNOS/NOS3 REFERENCES 12842859
TYPE JAK2( Janus kinase) REFERENCES 9287353

Coupling with G-proteins:
Family:Gq/11 REFERENCES:8865167
1GPR0030Galpha-11-Meleagris gallopavo


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athina University of Athens
Faculty of Biology
Dept. of Cell Biology and Biophysics
Biophysics
& Bioinformatics
Laboratory