gpDB: a database of GPCRs, G-proteins, Effectors and their interactions
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gpDB::GPCR View
Entry 1 of 1 :: GPCR0474 ::
CLASS CLASS A (RHODOPSIN LIKE)
FAMILY BRADYKININ RECEPTOR
SUBFAMILY B2

Cross References:
UniProt P32299 EMBL X69676 | X69682 | L26047 | X78438 | L27595
InterPro IPR001504 | IPR000496 | IPR000276 GPCRDB BKRB2_MOUSE
GENEID 12062
PRINTS PR00425 | PR00994 | PR00237 PFAM PF00001

Details:
NAME BRADYKININ RECEPTOR_B2_Mus musculus
DESCRIPTION B2 bradykinin receptor (BK-2 receptor) (B2R).
SPECIES Mus musculus COMMON NAME Mouse NCBI Taxonomy 10090
GENE Bdkrb2
SEQUENCE
MPCSWKLLGFLSVHEPMPTAASFGIEMFNVTTQVLGSALNGTLSKDNCPDTEWWSWLNAI
QAPFLWVLFLLAALENLFVLSVFFLHKNSCTVAEIYLGNLAAADLILACGLPFWAITIAN
NFDWVFGEVLCRVVNTMIYMNLYSSICFLMLVSIDRYLALVKTMSMGRMRGVRWAKLYSL
VIWGCTLLLSSPMLVFRTMREYSEEGHNVTACVIVYPSRSWEVFTNVLLNLVGFLLPLSV
ITFCTVRILQVLRNNEMKKFKEVQTERKATVLVLAVLGLFVLCWVPFQISTFLDTLLRLG
VLSGCWDEHAVDVITQISSYVAYSNSGLNPLVYVIVGKRFRKKSREVYRVLCQKGGCMGE
PVQMENSMGTLRTSISVERQIHKLQDWAGKKQ
FRAGMENT NO

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Dimerization:
HOMODIMER INFORMATION There is experimental evidence for homo-dimerization METHOD Cross-linking in the presence of agonist REFERENCES 10473556
HETERODIMER INFORMATION Forms heterodimer with Angiotensin AT1 Receptor. Dimerization results in increased signalling activity METHOD Immunoprecipitation REFERENCES 10993080

Scaffold:
TYPE eNOS( endothelial nitric oxide synthase) /cNOS/NOS3 REFERENCES 10681501
TYPE nNOS( neuronal nitric oxide synthase) NOS1 REFERENCES 10681501

Coupling with G-proteins:
Family:G12/13 REFERENCES:7946358
1GPR0035Galpha-12-Mus musculus
2GPR0038Galpha-13-Mus musculus-2
3GPR0323Galpha-13-Mus musculus-3
4GPR0380Galpha-13-Mus musculus-1
Family:Gq/11 REFERENCES:1657928
5GPR0031Galpha-11-Mus musculus-2
6GPR0240Galpha-q-Mus musculus
7GPR0360Galpha-11-Mus musculus-1


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athina University of Athens
Faculty of Biology
Dept. of Cell Biology and Biophysics
Biophysics
& Bioinformatics
Laboratory