gpDB: a database of GPCRs, G-proteins, Effectors and their interactions
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gpDB::GPCR View
Entry 1 of 1 :: GPCR0630 ::
CLASS CLASS A (RHODOPSIN LIKE)
FAMILY CHEMOKINE RECEPTOR (CX3C)
SUBFAMILY CXCR2

Cross References:
UniProt P25025 | Q8IUZ1 | Q9P2T6 | Q9P2T7 EMBL M73969 | M94582 | M99412 | L19593 | U11869 | AY714242 | BC037961 | AB032733 | AB032734
InterPro IPR001277 | IPR000276 | IPR000174 | IPR000057 GPCRDB CXCR2_HUMAN
GENEID 3579 MIM 146928
PRINTS PR00645 | PR00237 | PR00427 | PR00573 PFAM PF00001

Details:
NAME CHEMOKINE RECEPTOR (CX3C)_CXCR2_Homo sapiens
DESCRIPTION High affinity interleukin-8 receptor B (IL-8R B) (CXCR-2) (GRO/MGSAreceptor) (IL-8 receptor type 2) (CD182 antigen) (CDw128b).
SPECIES Homo sapiens COMMON NAME Human NCBI Taxonomy 9606
GENE IL8RB | CXCR2
SEQUENCE 
MEDFNMESDSFEDFWKGEDLSNYSYSSTLPPFLLDAAPCEPESLEINKYFVVIIYALVFL
LSLLGNSLVMLVILYSRVGRSVTDVYLLNLALADLLFALTLPIWAASKVNGWIFGTFLCK
VVSLLKEVNFYSGILLLACISVDRYLAIVHATRTLTQKRYLVKFICLSIWGLSLLLALPV
LLFRRTVYSSNVSPACYEDMGNNTANWRMLLRILPQSFGFIVPLLIMLFCYGFTLRTLFK
AHMGQKHRAMRVIFAVVLIFLLCWLPYNLVLLADTLMRTQVIQETCERRNHIDRALDATE
ILGILHSCLNPLIYAFIGQKFRHGLLKILAIHGLISKDSLPKDSRPSFVGSSSGHTSTTL
 FRAGMENT NO

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Dimerization:
HOMODIMER INFORMATION There is experimental evidence for homo-dimerization METHOD Immunoprecipitation REFERENCES 12888558

Scaffold:
TYPE beta-arrestin-1 - 2 REFERENCES 10973280

Coupling with G-proteins:
Family:Gi/o REFERENCES:1891716
1GPR0020Galpha-o1-Homo sapiens
2GPR0109Galpha-i3-Homo sapiens
3GPR0218Galpha-i1-Homo sapiens-1
4GPR0226Galpha-i2-Homo sapiens-2
5GPR0261Galpha-i1-Homo sapiens-2
6GPR0334Galpha-o-Homo sapiens
7GPR0365Galpha-i2-Homo sapiens-1

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athina University of Athens
 Faculty of Biology
 Dept. of Cell Biology and Biophysics
Biophysics
& Bioinformatics
Laboratory