gpDB: a database of GPCRs, G-proteins, Effectors and their interactions
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gpDB::GPCR View
Entry 1 of 1 :: GPCR0778 ::
CLASS CLASS A (RHODOPSIN LIKE)
FAMILY DOPAMINE RECEPTOR
SUBFAMILY D2

Cross References:
UniProt Q90WQ6 EMBL AJ347729
InterPro IPR001922 | IPR000929 | IPR000276 GPCRDB Q90WQ6_ONCMY
PRINTS PR00567 | PR00242 | PR00237 PFAM PF00001

Details:
NAME DOPAMINE RECEPTOR_D2_Oncorhynchus mykiss -2
DESCRIPTION Dopamine D2 receptor 2.
SPECIES Oncorhynchus mykiss COMMON NAME Rainbow trout NCBI Taxonomy 8022
GENE D2R2
SEQUENCE
MDVLTQYAYNESFWDNGNGSFNDTESGQKHPYNYYAMLLTLLILVIVFGNVLVCMAVSRE
KALQSTTNYLIVSLAVADLLVATLVMPWVVYLEVVGEWRFNKIHCDIFVTLDVMMCTASI
LNLCAISIDRYTAVAMPMLYNTRYSSRRRVTVMISVVWVLSFAISCPLLFGLNNTATRDE
SLCIIANPAFVVYSSIVSFYIPFIITLLVYVQIYVVLRKRRKRVNTKRPCQGTGDHDAGA
TLKEKCSHPGDVRLCTVIVKPNGSFPVNKKKVIFIKEVAHEGDDIELDEMTNCNPQKQKN
VDNATATPVSHQLLPPTKANAAPTSVPPSPPGSSVKVEKNGDSKDILVEVPKVTKAFQTE
ALPNGKTQTSIKQQPTLMSKRKISQQKEKKATQMLAIVLGVFIICWLPFFITHILNTHCT
TCKVPAEMYNAFTWLGYVNSAVNPIIYTTFNIEFRKAFIQILHC
FRAGMENT NO

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Dimerization:
HOMODIMER INFORMATION There is experimental evidence for homo-dimerization METHOD Fluorescence Resonance Energy Transfer (FRET) REFERENCES 11682068
HOMODIMER INFORMATION There is experimental evidence for homo-dimerization METHOD Immunoprecipitation REFERENCES 10860933
HETERODIMER INFORMATION Forms heterodimers with Dopamine D3 Receptors. Dimerization results in an Increased affnity and potency for agonists and antagonists METHOD Functional reconstitution REFERENCES 11373283
HETERODIMER INFORMATION Forms heterodimer with Somatostatin SST5 Receptor. Dimerization results in increased ligand binding affnity and enhanced signalling METHOD Photobleaching Fluorescence Resonance Energy Transfer (FRET) REFERENCES 10753124
HETERODIMER INFORMATION Forms heterodimers with Adenosine A2A Receptor. Heterodimerization results in co-desensitization and co-internalization of the receptors METHOD Immunoprecipitation REFERENCES 11872740

Scaffold:
TYPE alpha-filamin/ABP280( actin binding protein 280) REFERENCES 11911837 | 1239393
TYPE Protein 4.1N REFERENCES 12181426
TYPE Spinophilin/neurabin II REFERENCES 10391935

Coupling with G-proteins:
No information


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athina University of Athens
Faculty of Biology
Dept. of Cell Biology and Biophysics
Biophysics
& Bioinformatics
Laboratory