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gpDB::GPCR View
Entry 1 of 1 :: GPCR0868 ::
CLASS CLASS A (RHODOPSIN LIKE)
FAMILY GLYCOPROTEIN HORMONE RECEPTOR
SUBFAMILY LSH RECEPTOR

Cross References:
UniProt Q28005 | P79133 | Q8SPS8 EMBL U20504 | AF491303 | U87230
InterPro IPR000276 | IPR002131 | IPR001611 | IPR000372 | IPR002273 GPCRDB LSHR_BOVIN
GENEID 281900
PRINTS PR00373 | PR00237 | PR01144 PFAM PF00001 | PF00560

Details:
NAME GLYCOPROTEIN HORMONE RECEPTOR_LSH RECEPTOR_Bos taurus-2
DESCRIPTION Lutropin-choriogonadotropic hormone receptor precursor (LH/CG-R) (LSH-R) (Luteinizing hormone receptor).
SPECIES Bos taurus COMMON NAME Bovine NCBI Taxonomy 9913
GENE LHCGR
SEQUENCE 
MGRPSLALRLLLALLLLPPPAPLLWALRPAPCPEPCSCPPDGALRCPGPQAGLSRLSLTY
LPIKVIPSQAFRGLNEVIKIEISQSDSLEKIEANAFDNLLNLSEILIQNTKNLVHIEAGA
FTNLPRLKYLSICNTGIHKLPDVTKIFSSEFNFILEICDNLHITTIPRNAFQGMNNESIT
LKLYGNGFEEIQSHAFNGTTLISLELKENARLEKMHNDAFRGATGPSILDISSTKLQALP
TYGLESIQTLIATSSYSLKKLPSREKFTNLLDATLTYPSHCCAFRNLPTNEQNFSFSIFK
NFSKQCESTARRPNNETLYSAIFAESELSGWDYDYGFCLPKTLQCAPEPDAFNPCEDIMG
YNFLRVLIWLINILAITGNVTVLFVLLTSRYKLTVPRFLMCNLSFADFCMGLYLLLIASV
DAQTKGQYYNHAIDWQTGSGCSAAGFFTVFASELSVYTLTVITLERWHTITYAIQLDQKL
RLKHAIPVMLGGWLFSTLIAVLPLVGVSNYMKVSICLPMDVESTLSQVYILTILILNVMA
FIIICACYIKIYFAVQNPELMATNKDTKIAKKMAVLIFTDFTCMAPISFFAISAAFKVPL
ITVTNSKVLLVLFYPVNSCANPFLYAIFTKAFQRDFFLLLSKFGCCKYRAELYRRKDFSA
YISNCKNGFTGSNKPSRSTFKLTTLQCQYSAVLDKTCYKEC
 FRAGMENT NO

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Dimerization:
HOMODIMER INFORMATION There is experimental evidence for homo-dimerization METHOD Photobleaching Fluorescence Resonance Energy Transfer (FRET) REFERENCES 11108263

Scaffold:
TYPE GIPC( GAIP-interacting protein) REFERENCES 14507927
TYPE NHERF1( Na+/H+ exchange regulatory factor) /EBP50( ezrin-radixin-moesin binding phosphoprotein 50-kD protein) REFERENCES 14507927
TYPE p38JAB1 REFERENCES 10788448

Coupling with G-proteins:
Family:Gi/o REFERENCES:1516719
1GPR0017Galpha-o1-Bos taurus
2GPR0219Galpha-i1-Bos taurus
3GPR0294Galpha-i2-Bos taurus-2
4GPR0295Galpha-i2-Bos taurus-1
Family:Gq/11 REFERENCES:1516719
5GPR0027Galpha-11-Bos taurus
Family:Gs REFERENCES:1516719
6GPR0114Galpha-s-Bos taurus

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athina University of Athens
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 Dept. of Cell Biology and Biophysics
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