Photo Dr. Nikos Papandreou

2005 Defended PhD thesis

1997 - 2005: PhD student in the Department of Cell Biology and Biophysics, Faculty of Biology, University of Athens.
Title: "Contribution in the study of substrate selectivity of the enzyme Dihydrofolate Reductase (DHFR). Structural and biochemical studies of novel inhibitors of the enzyme and their complexes."
Supervisor: Professor Stavros J. Hamodrakas

1992 - 1997:Undergraduate studies in the Faculty of Biology, University of Athens.
Diploma Thesis: "Structural studies of the plant lectin Concanavalin A (Con A)."
Supervisor: Professor Stavros J. Hamodrakas

My research interests are oriented towards the determination of structural features of proteins and small organic compounds by X-Ray crystallographic methods. At present my research is focused on structural studies of the enzyme Dihydrofolate Reductase.
I am also interested in the determination of protein structures by comparative modeling, in cases where no experimental data can be obtained.


Nastou, K.C., Tsaousis, G.N., Papandreou, N.C., Hamodrakas, S.J. (2016) MBPpred: Proteome-wide detection of membrane lipid-binding proteins using profile Hidden Markov Models. Biochim. Biophys. Acta Volume 1864, Issue 7, pp. 747–754. [Abstract] doi: 10.1016/j.bbapap.2016.03.015.

Rerra, A.I.G., Grimanelli, V.P., Papandreou, N.C., Hamodrakas, S.J. (2016) Optimizing the Aggregation Propensity of Therapeutic Monoclonal Antibodies against Cancer and Autoimmune Diseases: A Computational Study. Int. J. Biochem. Res. Rev. 10(1): 1-15, 2016, Article no.IJBcRR.23216.  doi: 10.9734/IJBCRR/2016/23216 [Abstract]

Papadimitriou, K., Anastasiou, R., Maistrou, E., Plakas, T., Papandreou, N.C., Hamodrakas, S.J., Ferreira, S., Supply, P., Renault, P., Pot, B., Tsakalidou, E. (2015) Acquisition through horizontal gene transfer of plasmid pSMA198 by Streptococcus macedonicus ACA-DC 198 points towards the dairy origin of the species.PLoS One. 2015 Jan 13;10(1):e0116337. doi: 10.1371/journal.pone.0116337 [Abstract]

Ioannidou, Z.S., Theodoropoulou, M.C., Papandreou, N.C., Willis, J.H., Hamodrakas, S.J. (2014) CutProtFam-Pred: Detection and classification of putative structural cuticular proteins from sequence alone, based on profile Hidden Markov Models. Insect. Biochem. Mol. Biol., Volume 52, September 2014, Pages 51-59. doi: 10.1016/j.ibmb.2014.06.004 [Abstract]

Papadimitriou, K., Anastasiou, R., Mavrogonatou, E., Blom, J., Papandreou, N.C., Hamodrakas, S.J., Ferreira, S., Renault, P., Supply, P., Pot, B., Tsakalidou, E. (2014) Comparative genomics of the dairy isolate Streptococcus macedonicus ACA-DC 198 against related members of the Streptococcus bovis/Streptococcus equinus complex. BMC Genomics, 15:272. doi: 10.1186/1471-2164-15-272 [Abstract]

Giannopoulos, N.G., Michalopoulos, I., Papandreou, N.C., Malatras, A., Iconomidou, V.A., Hamodrakas, S.J. (2013) LepChorionDB, a database of Lepidopteran chorion proteins and a set of tools useful for the identification of chorion proteins in Lepidopteran proteomes. Insect Biochem Mol Biol. , 43: 189-196. [Abstract]

Tsolis, A.C., Papandreou, N.C., Iconomidou, V.A., Hamodrakas, S.J. (2013) A Consensus Method for the Prediction of "Aggregation-Prone" Peptides in Globular Proteins. PLoS ONE, 8(1): e54175. [Abstract]

Willis, J.H., Papandreou, N.C., Iconomidou, V.A., Hamodrakas, S.J. (2012) Cuticular proteins. Chapter 5 in Insect Molecular Biology and Biochemistry (ed. L. I. Gilbert) Academic Press pp. 134-166.

Papadimitriou K., S. Ferreira, N.C. Papandreou, E. Mavrogonatou, P. Supply, B. Pot and E. Tsakalidou (2012) Complete genome sequence of the dairy isolate Streptococcus macedonicus ACA-DC 198. Journal of Bacteriology, 194: 1838-1839.[Abstract]

Satagopam, V.P., Theodoropoulou, M.C., Stampolakis, C.K., Pavlopoulos, G.A., Papandreou, N.C., Bagos, P.G., Schneider, R., Hamodrakas, S.J. (2010) GPCRs, G-proteins, Effectors and their interactions: Human-gpDB, a database employing advanced visualization tools and data integration techniques. Database (Oxford), 2010. [Abstract]

Papandreou, N.C., Iconomidou, V.A., Willis, J.H., Hamodrakas, S.J.(2010) A possible structural model of members of the CPF family of cuticular proteins implicating binding to components other than chitin. J Insect Physiol., 56(10): 1420-1426.[Abstract]

Kastritis, P.L., Papandreou, N.C., Hamodrakas, S.J. (2007) Haloadaptation: Insights from comparative modeling studies of halophilic archaeal DHFRs. Int. J.Biol. Macromol. 41(4): 447-53. [Abstract]

Papandreou N.C., Makedonopoulou S., Antoniadou-Vyza E.A., Mavridis I.M., Hamodrakas S.J. (2002) 2,4-Diamino-5-(1-naphthyl)-3,5-diaza-1-azoniaspiro[5.5]undeca-1,3-diene chloride. Acta Crystallogr C. , 58, 730-732. [Abstract]