gpDB: a database of GPCRs, G-proteins, Effectors and their interactions
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gpDB::Effector View
Entry 1 of 1 :: EFF0445 ::
FAMILY Guanine nucleotide exchange factors
SUBFAMILY RhoGEFs
TYPE PDZ RhoGEF

Cross References:
UniProt O15085 | Q5VY40 EMBL AB002378 | AL356104 | AL157713 | AL157713 | AL356104
InterPro IPR000219 | IPR001331 | IPR001478 | IPR001849 | IPR011993 | IPR000342 | IPR015212 | IPR015721 PDB 1HTJ | 1XCG | 2DLS
GENEID 9826 MIM 605708
PFAM PF00595 | PF09128 | PF00621

Details:
NAME PDZ RhoGEF-Homo sapiens-2
DESCRIPTION Rho guanine nucleotide exchange factor 11 (PDZ-RhoGEF).
SPECIES Homo sapiens COMMON NAME Human NCBI Taxonomy 9606
GENE ARHGEF11 | KIAA0380
SEQUENCE 
MSVRLPQSIDRLSSLSSLGDSAPERKSPSHHRQPSDASETTGLVQRCVIIQKDQHGFGFT
VSGDRIVLVQSVRPGGAAMKAGVKEGDRIIKVNGTMVTNSSHLEVVKLIKSGAYVALTLL
GSSPSSMGISGLQQDPSPAGAPRITSVIPSPPPPPPLPPPQRITGPKPLQDPEVQKHATQ
ILRNMLRQEEKELQDILPLYGDTSQRPSEGRLSLDSQEGDSGLDSGTERFPSLSESLMNR
NSVLSDPGLDSPRTS
 FRAGMENT NO
FUNCTION May play a role in the regulation of RhoA GTPase bys guanine nucleotide-binding alpha-12 (GNA12) and alpha-13 (GNA13)
Interacting with G-proteins:
Family:G12/13 REFERENCES:15251227 | 11799111 | 14607242
1GPR0034Galpha-12-Homo sapiens
2GPR0037Galpha-13-Homo sapiens
Family:Gq/11 REFERENCES:1525227 | 16182515
3GPR0002Galpha-q-Homo sapiens-2
4GPR0237Galpha-q-Homo sapiens-1

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